Mississauga girl loses 2 limbs after infection doctors thought was influenza

On an otherwise routine Tuesday evening in February, 11-year-old NupurMate was complaining at home about a headache.

The Mississauga girl had a 39 C feverand her symptoms seemed to be those of a common cold or influenza. But when Nupur couldn't stop shivering, herfamily took her tothe emergency room at nearby Trillium Hospital.

That hospital visit becamethe first of two times her parents were told their daughter had influenza andcould recover at home.

The third time Nupur'sparents took her to the hospital, her heart stopped, and she had to be resuscitated.

Nupurhas since hadtwo limbs amputated her left arm and right leg and is surviving on dialysis at the Hospital for Sick Children, following a diagnosis of aserious bacterial infection caused by streptococcus A. Her family is now questioning whyTrillium Hospitaldoctors didn't pick up on the severityof Nupur's symptoms sooner.

"One day, fever OK. But three days, plus the pain you don't just say 'oh, it's flu,'" her mother Sunita told CBC Toronto.

Doctors all thought flu

Sunita said her daughter rarely gets sick.This time was different.

Initially, the family's doctor advised rest andTylenol to keepNupur'sfever down.

Then, when the family went to Trillium on Feb. 21, they waited four hours to see a doctor, Sunita said, adding that nurses were dismissing her concerns that her daughter had something worse than the flu. Frustrated, Sunita and Nupur went home to rest instead.

The next morning,Nupur woke up wincing with severe pain in her left arm and right leg, so they again rushed her to the emergency room.

This time, shehadblood work and X-rays. They all came back clear.

"Everything points to influenza B," Sunitarecalled the doctor saying, but that diagnosisdidn't sit right with her.

"As far as I know, flu meant whole body pains, not in a particular part," she said.

Not flu, buta serious infection

It turned out a bacterial infection was attacking Nupur's body at a rapid pace. By Friday, her hands and feet felt cold to the touch.

"As a mom, I was doing all that I can. I put socks on her, I was rubbing her hands.After one hour, she said she doesn't have any feeling she was completely numb," Sunitarecalled.

Sunita called 911 that evening.

Nupur's blood pressure was plummeting in the ambulance back to Trillium, her mom said. "She was so pale.It was the first time I felt I was losing my daughter," Sunita said.

'I heard a nurse say, 'She's dead.'"-Nupur Mate's mother, Sunita

Soon after arriving,Nupur's heart stopped. "I heard a nurse say, 'She's dead,' then everyone, doctors and nurses, rushed over."

Sunitasays 10 to 15 doctors took turns performing cardiopulmonary resuscitation on her daughter.

Nupur stabilizedand was taken to SickKids. Her body was pumped with antibiotics to stop the infection from attacking more of her insides, Sunita said.

While on life support for more than a week, and 17 days spent in the ICU at SickKids, blood culture tests finally revealed the real diagnosis: Nupurhad a bacterial infection caused by streptococcus A.

The next revelation was that they had to amputate to stop it from spreading, and therewas no saving the limbs Nupur had been complaining about: Physicians had tocut her left arm above the elbow and her right leg partially below the knee, her mom recalled.

Dr. Alison McGeer, infectious disease consultant at Mount Sinai hospital, says Nupur'sbacterial infection is extremely rare and that her case isan anomaly.

"Most often, streptococcus A will live in the nose and throat of people, and nothing will come of it," said McGeer, who is not involved in the family's health care.

• Strep infections that could threaten your life

She added it's a one-in-a-million instance for strep A to cause septic shockas it did in this case. There is also no vaccine to prevent a streptococcus A infection and no way to tell who can fight the infection and who cannot.

"The tragedy is that for two or three days this condition just looks like a regular viral illness," McGeer said. "And then all of the sudden, this very serious illness develops."

Sunitasaid when her daughter woke up to her missing arm and leg, she asked, "How did this happen? I only had a cough."

While Nupur's family is questioning why the infection wasn't discovered sooner,McGeersaid the doctors could not have predicted Mate'scondition would advance the way it did.

In a statement provided to CBC Toronto, Trillium Health Partners said they would not comment on the case due to patient confidentiality.

"When a patient presents at one of our emergency departments, they are assessed and triaged based on their current medical needs," the statement said.

Attacked everything but her spirit

After 17 days in the intensive care unit,Nupuris still atSickKidsspending hours on dialysis as her kidneysheal.

Sunitahas quit her job to be by her daughter's side during her recovery. It isn't clear when she will be well enough to go home, and her family has launched aGo Fund Me campaignto raise money to relieve some of the financial burden ofNupur'srecovery.

Once her kidneys stabilize, her long journey in rehabilitation with prosthetics will begin. Nupur always loved swimming lessons and karate classes, her mom said, and Sunitasaid she's told her everything she wanted todo, she still can.

"It attacked everything in her body but her spirit," she said.

Misdiagnosis leads to double amputation for little girl

7 years ago

Duration 1:51

Hospital visit became the first of two times her parents were told their daughter had influenza and could recover at home